Lodenafil Carbonate: Reproductive and Developmental Evaluation
نویسندگان
چکیده
منابع مشابه
[Cardiovascular repercussion of lodenafil carbonate, a new PDE5 inhibitor, with and without alcohol consumption].
BACKGROUND Millions of men around the world suffer from erectile dysfunction, for which phosphodiesterase 5 inhibitors (PDE-5 inhibitors) are currently the first treatment option. Sexual activity and alcohol consumption are closely related, and the simultaneous use of alcohol and PDE-5 inhibitors can happen. Lodenafil carbonate is a new PDE-5 inhibitor, developed by a Brazilian pharmaceutical c...
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Um método simples de eletroforese capilar de zona (CZE) foi desenvolvido e validado para análise de carbonato de lodenafila em comprimidos. A metodologia de superfície de resposta foi utilizada para a otimização do pH, concentração do tampão, voltagem e temperatura. O método utilizou como eletrólito, tampão borato 50 mmol L, pH 10, voltagem de 15 kV. A separação foi efetuada em capilar de sílic...
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A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction. These effects are of interest to teratologists, because animal studies are useful in their evaluation. Many of the epidemiology studies did not evaluate the impact of the "pregnancy signal," which identifies h...
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: Apical tests for reproductive or developmental toxicity assess the potential for a compound to affect any of the thousands of steps involved in making gametes and in the successful development of a fully functional offspring. Conventionally, this is thought to require at least 21 days for rodent female reproduction and for development, and close to 70 days for spermatogenesis. Short-term test...
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The task of informing workers of hazards in the workplace is seldom more difficult than with the subject of reproductive and developmental hazards. Occupational health staff and physicians are faced with a paucity of relevant medical information. Workers, kept aware of the thalidomide spectre with every media report of the latest descriptive epidemiology study, are anxious to know more. Employe...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.758.5